EPIDEMIOLOGY: Don't Keep Hedgehogs

Commentary: Epidemiology? Keep it broad and deep.

On hedgehogs and human cancer

in vitro, specifically decreasing GLI1 messenger RNA (mRNA) levels, at concentrations ranging from 1 to 10mM showing dose-dependent effects, modulated by serum levels. The best tests for specificity rely on mimicry by targeting SMOH with RNA interference (RNAi), the use of insensitive SMOH mutants and pathway epistatic analyses. Targeting SMOH through lentivector-mediated short hairpin RNA (shR...

Plane Lorentzian and Fuchsian hedgehogs

Parts of the Brunn-Minkowski theory can be extended to hedgehogs, which are envelopes of families of affine hyperplanes parametrized by their Gauss map. In [F], F. Fillastre introduced Fuchsian convex bodies, which are the closed convex sets of Lorentz-Minkowski space that are globally invariant under the action of a Fuchsian group. In this paper, we undertake a study of plane Lorentzian and Fu...

Dont Breathe and Drive? Pollutants Lurk inside Vehicles

The ability of human immunodeficiency virus type 1 (HIV-1) to develop high levels of genetic diversity, and thereby acquire mutations to escape immune pressures, contributes to the difficulties in producing a vaccine. Possibly no single HIV-1 sequence can induce sufficiently broad immunity to protect against a wide variety of infectious strains, or block mutational escape pathways available to ...

Some Have a Talent for Bargaining and Some Dont

In Bargaining Theory players di¤er from one another in either their valuation for the negotiated object and/or their time preferences. We suggest a model that incorporates "bargaining ability" as another source for heterogeneity across players. This bargaining ability for the buyer determines how many o¤ers he will be able to turn down before he walks away. For the seller this ability determine...